ea0037ep437 | Diabetes (complications & therapy) | ECE2015
Fernandez-Gomez Isaac
, Sablon-Carrazana Marquiza
, Bencomo Alberto
, Pasten-Hidalgo Karina
, Castillo-Rodriguez Rosa Angelica
, Dominguez Guadalupe
, Lara Reyna
, Jimenez Luis Felipe
, Moran Julio
, Altamirano-Bustamante Nelly
, Islas-Andrade Sergio
, Rodriguez-Tanty Chryslaine
, Garrido-Magana Eulalia
, Altamirano-Bustamante Myriam M
Introduction: Type 2 diabetes mellitus is a conformational disease (CD), characterised by deposition (fibrils and cytotoxic oligomers) of the human islet amyloid peptide (hIAPP). CDs have devastating effects on the sufferers and their caregivers, as well as a tremendous economic impact on families and the health system. Novel molecule candidates targeting self-assembled amyloidogenic proteins represent a potential therapeutic approach for CDs.Methods/des...